DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing
نویسندگان
چکیده
منابع مشابه
Correlation of Corneal Allograft Rejection with Tumor Necrosis Factors-Alpha Gene Polymorphism
Background: Correlations between bone marrow, heart, kidney, liver, skin and lung transplant rejection or survival with human cytokine gene polymorphisms have been described. There are also reports about the role of cytokines and Tumor Necrosis Factors-Alpha (TNF-α) on corneal transplant in animal models. Further studies are needed to clarify the role of cytokines in corneal allograft rejection...
متن کاملRejection of the kidney allograft.
Copyright © 2010 Massachusetts Medical Society. The science of kidney transplantation has progressed considerably in the past half-century largely because of an improved understanding of the role of the immune system in allograft rejection, the disentanglement of the molecular mechanisms underlying graft failure, and better management of immunosuppression.1,2 Rejection has always been the major...
متن کاملCorneal allograft rejection.
The cornea is avascular, enjoys relative immune privilege, and immunosuppressive treatment can be directly applied: yet data from all available reports indicate that allogeneic rejection is the commonest cause of corneal graft failure. In Australia, 5 year actuarial corneal graft survival is 72%: irreversible rejection accounts for at least 33% of all graft failures.' Graft survival is much sho...
متن کاملSuppression of Allograft Rejection
Suppressor T cells (Ts) 1 have been described in many allogeneic systems and may play a role in preventing allograft rejection in tolerized (1-5), antigenpretreated (6-9), passively enhanced (10, 11), or cyclosporin A-treated (12, 13) recipients with long-term surviving transplants. The interactions between the Ts and their target cells are largely undefined. If Ts cells were specific for the a...
متن کاملApoptosis is involved in acute cardiac allograft rejection in rats.
BACKGROUND Allograft rejection remains a major obstacle to long-term survival in heart transplantation. Recent studies have demonstrated that apoptotic cell death may occur in acute allograft rejection. The purpose of this study was to determine whether apoptotic cell death is involved in rat cardiac allograft rejection through both the perforin/granzyme pathway and the Fas/Fas ligand (Fas-L) p...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2016
ISSN: 1600-6135
DOI: 10.1111/ajt.14012